PIEZO2

Across TCGA pan-cancer cohorts, PIEZO2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PIEZO2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PIEZO2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIEZO2 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where PIEZO2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIEZO2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.779	<.001	12	view →
HNSC	Female	III,IV	+1.076	<.001	10	view →
LUAD	Female	II,III,IV	−0.971	<.001	9	view →
LUSC	Male	II,III,IV	−1.644	<.001	8	view →
LIHC	Female	II,III,IV	+1.496	<.001	7	view →
THCA	All	All	+0.484	<.001	7	view →
UCEC	All	All	−0.666	<.001	6	view →
COAD	Female	II,III,IV	−0.259	.022	4	view →
CHOL	All	All	+1.671	.003	2	view →
BLCA	Male	All	−0.925	.018	2	view →
READ	Female	All	−0.900	.019	2	view →
STAD	Male	II,III,IV	+0.399	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PIEZO2–KIRC

Open the KIRC breakdown →