PIEZO2

Across TCGA cell cohorts, PIEZO2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,511 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PIEZO2-associated GO terms across cancer lineages are Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure, Renal system process involved in regulation of systemic arterial blood pressure, and Electron transport chain. Each is linked with PIEZO2 in more than 9 cancer types. Because this analysis shows association rather than direction, both PIEZO2-to-partner and partner-to-PIEZO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure grouped by PIEZO2-low versus PIEZO2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIEZO2→partner) and Y-score (partner→PIEZO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure →	+1.648	+2.967	<.001	.002	3	10
BONE	Renal system process involved in regulation of systemic arterial blood pressure →	+1.431	+2.988	<.001	<.001	3	8
SKIN	Electron transport chain →	+0.069	+2.125	<.001	<.001	3	8
SOFT_TISSUE	Cytoplasmic translation →	+0.060	+1.583	<.001	.005	2	9
SOFT_TISSUE	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.070	+1.439	<.001	.001	3	7
LIVER	Protein exit from endoplasmic reticulum →	+0.145	+3.045	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,511 associations by consensus.

Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure by PIEZO2 expression — LIVER

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