PIEZO2

Across TCGA cell cohorts, PIEZO2 mutation is significantly associated with the RNA expression of many other genes, with 1,180 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIEZO2-associated genes across cancer lineages are PRPSAP2, ISOC1, and ADGRE3. Each is linked with PIEZO2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PIEZO2-to-partner and partner-to-PIEZO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRPSAP2 grouped by PIEZO2-low versus PIEZO2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIEZO2→partner) and Y-score (partner→PIEZO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRPSAP2 →	+0.578	+2.523	<.001	.003	3	4
LARGE_INTESTINE	ISOC1 →	+0.623	+2.364	<.001	<.001	3	3
SOFT_TISSUE	ADGRE3 →	+0.004	+4.392	<.001	.004	3	2
LUNG_SCLC	PPP4R1 →	+0.538	+3.321	.008	.002	3	2
LUNG_NSCLC_LUAD	NDC80 →	+0.525	+3.279	.001	<.001	3	2
LARGE_INTESTINE	SNU13 →	+0.369	+1.850	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,180 associations by consensus.

PRPSAP2 by PIEZO2 expression — LARGE_INTESTINE

Explore this box plot interactively →