PID1

Across TCGA patient cohorts, PID1 mutation is significantly associated with the RNA expression of many other genes, with 4,550 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PID1-associated genes across cancer lineages are TTTY2, MIR8055, and PIGW. Each is linked with PID1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PID1-to-partner and partner-to-PID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY2 grouped by PID1-low versus PID1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PID1→partner) and Y-score (partner→PID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TTTY2 →	+0.014	+7.954	<.001	.008	3	2
UCEC	MIR8055 →	+0.328	+1.464	.007	.001	3	2
UCEC	PIGW →	+0.631	+2.379	<.001	<.001	3	2
UCEC	GFRA1 →	-0.537	-2.375	.006	.003	3	2
UCEC	TMEM251 →	+0.429	+2.436	.001	.001	3	2
UCEC	RMND1 →	+0.571	+3.434	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,550 associations by consensus.

TTTY2 by PID1 expression — HNSC

Explore this box plot interactively →