PID1

Across TCGA pan-cancer cohorts, PID1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PID1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PID1 RNA is repressed in tumor relative to normal tissue. In most cancer types PID1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and BLCA are the cancer types where PID1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PID1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.952	<.001	12	view →
THCA	All	IV	−2.745	<.001	11	view →
BLCA	Male	IV	−3.935	<.001	10	view →
KICH	Female	All	−2.065	<.001	10	view →
LUAD	Male	III,IV	−2.686	<.001	9	view →
KIRP	All	II,III,IV	−1.443	<.001	9	view →
LUSC	Male	II,III,IV	−2.778	<.001	8	view →
KIRC	All	II,III,IV	−0.773	<.001	8	view →
UCEC	All	All	−3.623	<.001	6	view →
BRCA	All	III,IV	−2.205	<.001	6	view →
STAD	All	All	−1.251	<.001	5	view →
READ	All	All	−1.796	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PID1–COAD

Open the COAD breakdown →