PID1

Across TCGA patient cohorts, PID1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PID1-associated genes across cancer lineages are eIF4E, FoxM1, and Annexin_VII. Each is linked with PID1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PID1-to-partner and partner-to-PID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PID1-low versus PID1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PID1→partner) and Y-score (partner→PID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.142	+2.584	.011	.009	3	3
UCEC	FoxM1 →	+0.207	+1.594	.010	.021	3	2
UCEC	Annexin_VII →	-0.085	-1.415	.049	.010	3	2
UCEC	ATM →	-0.414	-1.643	.003	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.470	+1.867	.010	.004	3	2
UCEC	Cyclin-B1 →	+0.715	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eIF4E by PID1 expression — SKCM

Explore this box plot interactively →