PID1

Across TCGA cell cohorts, PID1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,071 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PID1-associated GO terms across cancer lineages are Negative regulation of purine nucleotide biosynthetic process, Negative regulation of ATP biosynthetic process, and Negative regulation of nucleotide biosynthetic process. Each is linked with PID1 in more than 16 cancer types. Because this analysis shows association rather than direction, both PID1-to-partner and partner-to-PID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of purine nucleotide biosynthetic process grouped by PID1-low versus PID1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PID1→partner) and Y-score (partner→PID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of purine nucleotide biosynthetic process →	-0.231	-2.755	<.001	<.001	3	17
SOFT_TISSUE	Negative regulation of ATP biosynthetic process →	-0.227	-2.575	<.001	<.001	3	17
SOFT_TISSUE	Negative regulation of nucleotide biosynthetic process →	-0.231	-2.755	<.001	<.001	3	17
LUNG_NSCLC_LUAD	Response to acetaldehyde →	+0.196	+1.006	.007	.001	3	9
LUNG_NSCLC_LUAD	Cellular response to acetaldehyde →	+0.196	+1.006	.007	.001	3	9
STOMACH	Positive regulation of cytoskeleton organization →	+0.048	+0.957	<.001	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,071 associations by consensus.

Negative regulation of purine nucleotide biosynthetic process by PID1 expression — SOFT_TISSUE

Explore this box plot interactively →