PID1

Across TCGA cell cohorts, PID1 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PID1-associated genes across cancer lineages are FAM71C, LCE4A, and AKAIN1. Each is linked with PID1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PID1-to-partner and partner-to-PID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71C grouped by PID1-low versus PID1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PID1→partner) and Y-score (partner→PID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FAM71C →	+0.012	+3.510	<.001	.003	3	1
SKIN	LCE4A →	+0.031	+4.022	<.001	.006	3	1
SKIN	AKAIN1 →	+0.040	+3.345	.004	.007	3	1
BLOOD_Leukemia	LUZP4 →	+0.485	+5.060	<.001	.001	3	1
BLOOD_Leukemia	ZP2 →	+0.158	+4.409	<.001	.005	3	1
BLOOD_Leukemia	MYL2 →	+0.916	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

FAM71C by PID1 expression — SKIN

Explore this box plot interactively →