PICSAR

Across TCGA pan-cancer cohorts, PICSAR RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PICSAR data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PICSAR RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PICSAR expression acts as an unfavorable survival marker, although some lineages such as ESCA and READ show a favorable association.

KIRP, LIHC, and LUAD are the cancer types where PICSAR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	III,IV	0.397	0.737	.001	74	view →
LIHC	OS	Tertile	All	0.377	0.582	<.001	50	view →
LUAD	DFS	Quartile	III,IV	0.476	0.777	.002	43	view →
MESO	OS	Median	All	0.289	0.476	.003	35	view →
GBM	OS	Median	All	0.281	0.519	.003	32	view →
COAD	DFS	Median	II,III,IV	0.686	0.844	.003	31	view →
LGG	OS	Tertile	All	0.839	0.939	<.001	30	view →
ACC	DFS	Median	All	0.520	0.782	.005	29	view →
PAAD	OS	Quartile	II,III,IV	0.403	0.712	.004	18	view →
ESCA	OS	Tertile	III,IV	0.731	0.390	.004	18	view →
READ	DFS	Quartile	II,III,IV	0.931	0.331	.014	18	view →
STAD	DFS	Median	All	0.303	0.475	.017	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PICSAR–KIRP (DFS)

Open the KIRP breakdown →