PICSAR

Across TCGA pan-cancer cohorts, PICSAR RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PICSAR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PICSAR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PICSAR is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where PICSAR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PICSAR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.765	<.001	10	view →
KIRC	Male	III,IV	+0.305	<.001	9	view →
LUAD	Female	II,III,IV	−1.679	<.001	8	view →
THCA	Male	All	+0.355	<.001	8	view →
BRCA	All	III,IV	−1.421	<.001	6	view →
LUSC	Female	II,III,IV	−1.922	<.001	5	view →
KIRP	All	IV	+0.092	.002	4	view →
BLCA	All	All	+0.603	.048	2	view →
PRAD	All	All	+0.203	.006	2	view →
LIHC	All	All	+0.038	.020	2	view →
CHOL	All	All	+0.265	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PICSAR–HNSC

Open the HNSC breakdown →