PICK1

Across TCGA cell cohorts, PICK1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PICK1-associated genes across cancer lineages are SERPINA10, NPFFR1, and DEFB125. Each is linked with PICK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PICK1-to-partner and partner-to-PICK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA10 grouped by PICK1-low versus PICK1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PICK1→partner) and Y-score (partner→PICK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SERPINA10 →	+0.079	+3.912	.004	.006	3	1
BLOOD_Leukemia	NPFFR1 →	+0.015	+4.037	<.001	.004	3	1
BLOOD_Leukemia	DEFB125 →	+0.035	+4.060	<.001	.003	3	1
BLOOD_Leukemia	TBPL2 →	+0.111	+4.044	<.001	.004	3	1
BLOOD_Leukemia	CCT8L2 →	+0.011	+3.874	<.001	.005	3	1
BLOOD_Leukemia	KHDC3L →	+0.274	+3.774	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SERPINA10 by PICK1 expression — BLOOD_Leukemia

Explore this box plot interactively →