PICALM

Across TCGA pan-cancer cohorts, PICALM Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PICALM data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PICALM Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PICALM expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, LIHC, and HNSC are the cancer types where PICALM Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.610	0.934	<.001	36	view →
LIHC	OS	Median	All	0.079	0.774	<.001	30	view →
HNSC	OS	Median	II,III,IV	0.059	0.712	<.001	30	view →
UCEC	DFS	Median	All	0.940	0.626	.026	14	view →
LUAD	OS	Median	All	0.276	0.697	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PICALM–KIRP (OS)

Open the KIRP breakdown →