PICALM

Across TCGA pan-cancer cohorts, PICALM RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PICALM’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PICALM RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PICALM is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

HNSC, STAD, and BRCA are the cancer types where PICALM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PICALM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.901	<.001	11	view →
STAD	All	II,III,IV	+0.667	.002	8	view →
BRCA	All	All	−0.299	<.001	6	view →
ESCA	All	All	+0.788	.003	4	view →
LUAD	Male	II,III,IV	+0.540	.015	4	view →
CHOL	All	All	+1.198	<.001	3	view →
LIHC	All	All	+0.302	.008	3	view →
UCEC	All	All	−0.786	<.001	2	view →
BLCA	Male	IV	+0.427	.007	2	view →
PRAD	All	All	+0.322	.002	2	view →
KICH	Male	III,IV	−0.557	.034	1	view →
READ	Female	All	−0.500	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PICALM–HNSC

Open the HNSC breakdown →