PICALM

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PICALM protein abundance is significantly associated with the RNA expression of many other genes, with 19,904 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PICALM-associated genes across cancer lineages are ATP8B4, PDE1B, and GAB3. Each is linked with PICALM in more than 8 cancer types. Because this analysis shows association rather than direction, both PICALM-to-partner and partner-to-PICALM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PICALM versus ATP8B4 in HNSC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PICALM→partner) and Y-score (partner→PICALM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCATP8B4 →+0.902+0.224<.001.00139
OVPDE1B →+1.041+0.351<.001<.00139
HNSCGAB3 →+0.900+0.253<.001<.00139
COADPTGDR →+0.875+0.195<.001<.00139
OVIL16 →+1.029+0.336<.001<.00139
OVMYLK →+1.196+0.304<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 19,904 associations by consensus.

PICALM vs ATP8B4 — HNSC

Per-sample scatter of PICALM vs ATP8B4 in HNSC (Pearson r = 0.39).

Explore this scatter interactively →

Exploration