PICALM

Across TCGA patient cohorts, PICALM mutation is significantly associated with the RNA expression of many other genes, with 2,721 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PICALM-associated genes across cancer lineages are BNIP3P7, RN7SL655P, and RPL17-C18orf32. Each is linked with PICALM in more than 1 cancer types. Because this analysis shows association rather than direction, both PICALM-to-partner and partner-to-PICALM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P7 grouped by PICALM-low versus PICALM-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PICALM→partner) and Y-score (partner→PICALM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	BNIP3P7 →	+0.432	+5.219	<.001	.006	3	2
LUSC	RN7SL655P →	+0.110	+3.922	<.001	.002	3	2
COAD	RPL17-C18orf32 →	+0.079	+3.010	.001	.006	3	2
COAD	SS18L2P2 →	+0.127	+4.332	<.001	.006	3	2
SKCM	RNU5E-9P →	+0.194	+4.897	<.001	.002	3	2
UCEC	NUDT22 →	+0.375	+2.010	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,721 associations by consensus.

BNIP3P7 by PICALM expression — READ

Explore this box plot interactively →