PICALM

Across TCGA patient cohorts, PICALM mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PICALM-associated genes across cancer lineages are ATM, EGFR_pY1068, and mTOR_pS2448. Each is linked with PICALM in more than 2 cancer types. Because this analysis shows association rather than direction, both PICALM-to-partner and partner-to-PICALM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PICALM-low versus PICALM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PICALM→partner) and Y-score (partner→PICALM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.399	-1.652	.007	.006	3	3
UCEC	EGFR_pY1068 →	-0.205	-1.652	.013	.006	3	2
UCEC	mTOR_pS2448 →	-0.165	-2.571	<.001	<.001	3	2
UCEC	PCNA →	+0.211	+3.584	.002	.002	3	2
UCEC	PDCD4 →	-0.534	-1.938	<.001	.001	3	2
UCEC	Caspase-8 →	-0.252	-4.295	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by PICALM expression — UCEC

Explore this box plot interactively →