PICALM

Across TCGA cell cohorts, PICALM RNA expression is significantly associated with the go_rna of many other GO terms, with 5,409 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PICALM-associated GO terms across cancer lineages are Regulation of focal adhesion assembly, Regulation of cell-substrate junction assembly, and Cellular response to abiotic stimulus. Each is linked with PICALM in more than 13 cancer types. Because this analysis shows association rather than direction, both PICALM-to-partner and partner-to-PICALM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of focal adhesion assembly grouped by PICALM-low versus PICALM-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PICALM→partner) and Y-score (partner→PICALM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of focal adhesion assembly →	+0.140	+0.735	<.001	<.001	3	14
BONE	Regulation of cell-substrate junction assembly →	+0.140	+0.735	<.001	<.001	3	14
BONE	Cellular response to abiotic stimulus →	+0.055	+1.150	.001	<.001	3	13
BONE	Cellular response to environmental stimulus →	+0.055	+1.150	.001	<.001	3	13
BONE	Regulation of cell-substrate junction organization →	+0.194	+1.200	<.001	<.001	3	13
BONE	Endothelial cell differentiation →	+0.115	+0.784	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,409 associations by consensus.

Regulation of focal adhesion assembly by PICALM expression — BONE

Explore this box plot interactively →