PICALM

Across TCGA cell cohorts, PICALM mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PICALM-associated genes across cancer lineages are ZAN, SMIM9, and SCYGR10. Each is linked with PICALM in more than 1 cancer types. Because this analysis shows association rather than direction, both PICALM-to-partner and partner-to-PICALM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by PICALM-low versus PICALM-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PICALM→partner) and Y-score (partner→PICALM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZAN →	+0.004	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	SMIM9 →	+0.021	+4.734	.006	.002	3	1
LUNG_NSCLC_LUAD	SCYGR10 →	+0.157	+4.212	.006	.007	3	1
LARGE_INTESTINE	C2orf42 →	+0.600	+3.215	.001	.009	3	1
LARGE_INTESTINE	RAB14 →	+0.515	+3.064	.007	.009	3	1
LARGE_INTESTINE	HRK →	+0.501	+3.241	.008	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ZAN by PICALM expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →