PIBF1

Across TCGA pan-cancer cohorts, PIBF1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIBF1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PIBF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIBF1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where PIBF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.465	0.816	.001	38	view →
LUAD	OS	Tertile	II,III,IV	0.744	0.407	.013	14	view →
LSCC	DFS	Median	All	0.864	1.000	.001	14	view →
OV	DFS	Median	All	1.000	0.854	.037	4	view →
UCEC	DFS	Quartile	All	0.976	0.839	.041	2	view →
GBM	DFS	Quartile	All	0.461	0.205	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIBF1–HNSC (DFS)

Open the HNSC breakdown →