PIBF1

Across TCGA pan-cancer cohorts, PIBF1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PIBF1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PIBF1 RNA is repressed in tumor relative to normal tissue. In most cancer types PIBF1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LIHC, and COAD are the cancer types where PIBF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIBF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.882	<.001	9	view →
LIHC	Male	All	+0.653	<.001	8	view →
COAD	Male	All	+0.902	<.001	7	view →
HNSC	All	All	+0.451	.004	7	view →
CHOL	Male	All	+1.494	<.001	4	view →
STAD	All	II,III,IV	+0.712	.001	4	view →
READ	All	III,IV	+0.694	.006	4	view →
THCA	Male	III,IV	−0.551	.006	4	view →
ESCA	All	All	+0.733	.005	2	view →
KIRP	All	IV	+0.730	.012	2	view →
UCEC	All	All	−0.633	.002	2	view →
LUSC	Male	III,IV	−0.632	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PIBF1–KICH

Open the KICH breakdown →