PIBF1

Across TCGA patient cohorts, PIBF1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIBF1-associated genes across cancer lineages are PCNA, GSK-3_pS9, and Acetyl-a-Tubulin-Lys40. Each is linked with PIBF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIBF1-to-partner and partner-to-PIBF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PIBF1-low versus PIBF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIBF1→partner) and Y-score (partner→PIBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.227	+3.459	.002	.005	3	3
UCEC	GSK-3_pS9 →	-0.369	-2.000	.009	.029	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.379	+2.999	.035	.035	3	2
UCEC	INPP4B →	-0.350	-3.999	.002	<.001	3	2
UCEC	ATM →	-0.436	-1.700	.006	.042	3	2
UCEC	C-Raf →	+0.149	+1.678	.003	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PCNA by PIBF1 expression — UCEC

Explore this box plot interactively →