PIAS4

Across TCGA pan-cancer cohorts, PIAS4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PIAS4 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PIAS4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PIAS4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where PIAS4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.902	0.707	.002	46	view →
UCEC	OS	Median	All	1.000	0.906	.009	26	view →
CCRCC	OS	Tertile	All	0.957	0.711	.009	15	view →
GBM	OS	Median	All	0.250	0.460	.013	4	view →
LUAD	OS	Quartile	All	1.000	0.938	.036	3	view →
PDAC	DFS	Median	IV	0.203	0.618	.047	3	view →
HNSC	DFS	Median	III,IV	0.698	1.000	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PIAS4–LSCC (OS)

Open the LSCC breakdown →