PIAS4

Across TCGA patient cohorts, PIAS4 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIAS4-associated genes across cancer lineages are FOXO3a_pS318_S321, 14-3-3_beta, and EGFR_pY1068. Each is linked with PIAS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIAS4-to-partner and partner-to-PIAS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by PIAS4-low versus PIAS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS4→partner) and Y-score (partner→PIAS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.112	-1.990	.026	.030	3	2
UCEC	14-3-3_beta →	-0.087	-3.295	.032	.009	3	1
UCEC	EGFR_pY1068 →	-0.208	-1.906	.040	.016	3	1
UCEC	A-Raf_pS299 →	-0.151	-2.584	.001	.010	3	1
UCEC	JNK2 →	+0.275	+1.884	<.001	.030	3	1
UCEC	Ku80 →	+0.364	+3.335	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FOXO3a_pS318_S321 by PIAS4 expression — UCEC

Explore this box plot interactively →