PIAS4

Across TCGA cell cohorts, PIAS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,637 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIAS4-associated GO terms across cancer lineages are Regulation of protein localization to chromatin, Negative regulation of protein localization to chromatin, and Subtelomeric heterochromatin formation. Each is linked with PIAS4 in more than 19 cancer types. Because this analysis shows association rather than direction, both PIAS4-to-partner and partner-to-PIAS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to chromatin grouped by PIAS4-low versus PIAS4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS4→partner) and Y-score (partner→PIAS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of protein localization to chromatin →	+0.199	+1.187	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Negative regulation of protein localization to chromatin →	+0.243	+1.274	<.001	<.001	3	19
SOFT_TISSUE	Subtelomeric heterochromatin formation →	+0.139	+0.973	<.001	<.001	3	18
PANCREAS	Positive regulation of protein sumoylation →	+0.116	+0.779	<.001	<.001	3	18
OESOPHAGUS	Positive regulation of gene expression, epigenetic →	+0.075	+0.928	.001	<.001	3	17
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.141	+0.632	.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,637 associations by consensus.

Regulation of protein localization to chromatin by PIAS4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →