PIAS4

Across TCGA cell cohorts, PIAS4 mutation is significantly associated with the RNA expression of many other genes, with 251 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIAS4-associated genes across cancer lineages are APOL5, LGALS13, and OBP2A. Each is linked with PIAS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIAS4-to-partner and partner-to-PIAS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOL5 grouped by PIAS4-low versus PIAS4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS4→partner) and Y-score (partner→PIAS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOL5 →	+0.012	+4.060	.002	.003	3	2
LUNG_NSCLC_LUSC	LGALS13 →	+0.099	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OBP2A →	+0.046	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR7A10 →	+0.063	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	FSHB →	+0.016	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TAAR5 →	+0.093	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 251 associations by consensus.

APOL5 by PIAS4 expression — BLOOD_Leukemia

Explore this box plot interactively →