PIAS1

Across TCGA pan-cancer cohorts, PIAS1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIAS1 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PIAS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PIAS1 expression acts as an unfavorable survival marker.

HNSC, KIRP, and CESC are the cancer types where PIAS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.176	0.685	.024	30	view →
KIRP	OS	Median	All	0.608	0.903	.012	9	view →
CESC	OS	Median	II,III,IV	0.227	0.759	.029	6	view →
KIRC	DFS	Median	III,IV	0.224	0.744	.044	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PIAS1–HNSC (OS)

Open the HNSC breakdown →