PIAS1

Across TCGA pan-cancer cohorts, PIAS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIAS1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PIAS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PIAS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and GBM are the cancer types where PIAS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	1.000	0.306	.013	15	view →
CCRCC	DFS	Median	III,IV	0.778	0.292	.002	14	view →
GBM	DFS	Median	All	0.278	0.493	.027	5	view →
UCEC	DFS	Median	II,III,IV	0.550	0.865	.027	4	view →
LUAD	DFS	Median	All	0.948	0.681	.016	4	view →
PDAC	OS	Quartile	All	0.822	0.434	.001	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIAS1–HNSC (DFS)

Open the HNSC breakdown →