PIAS1

Across TCGA patient cohorts, PIAS1 mutation is significantly associated with the RNA expression of many other genes, with 1,725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIAS1-associated genes across cancer lineages are PGK1, MLX, and LRRC59. Each is linked with PIAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIAS1-to-partner and partner-to-PIAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGK1 grouped by PIAS1-low versus PIAS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS1→partner) and Y-score (partner→PIAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGK1 →	+0.648	+2.743	.005	.002	3	2
UCEC	MLX →	+0.503	+2.950	<.001	<.001	3	2
UCEC	LRRC59 →	+0.485	+2.403	.001	<.001	3	2
UCEC	SLC35B1 →	+0.428	+2.021	<.001	.001	3	2
UCEC	ENOPH1 →	+0.490	+2.243	<.001	.005	3	2
KIRC	RNA5SP424 →	+0.316	+5.090	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,725 associations by consensus.

PGK1 by PIAS1 expression — UCEC

Explore this box plot interactively →