PIAS1

Across TCGA patient cohorts, PIAS1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIAS1-associated genes across cancer lineages are A-Raf_pS299, mTOR_pS2448, and eEF2. Each is linked with PIAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIAS1-to-partner and partner-to-PIAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PIAS1-low versus PIAS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS1→partner) and Y-score (partner→PIAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.140	-2.584	.001	.010	3	2
UCEC	mTOR_pS2448 →	-0.140	-2.395	.012	.003	3	2
UCEC	eEF2 →	+0.297	+1.700	.027	.042	3	1
UCEC	EGFR →	-0.184	-2.584	.002	.010	3	1
UCEC	eIF4E →	+0.188	+2.472	.017	.010	3	1
UCEC	ERK2 →	+0.244	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

A-Raf_pS299 by PIAS1 expression — UCEC

Explore this box plot interactively →