PIAS1

Across TCGA cell cohorts, PIAS1 mutation is significantly associated with the mutation status of many other genes, with 1,180 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIAS1-associated genes across cancer lineages are TSC22D1, PPARD, and FIBP. Each is linked with PIAS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIAS1-to-partner and partner-to-PIAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSC22D1 grouped by PIAS1-low versus PIAS1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS1→partner) and Y-score (partner→PIAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TSC22D1 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	PPARD →	+5.772	+5.772	.002	.002	1	3
LUNG_NSCLC_LUAD	FIBP →	+4.772	+5.339	.004	.004	1	3
LUNG_NSCLC_LUAD	BAZ2A →	+5.772	+5.772	.002	.002	1	3
CNS	HMGXB3 →	+5.614	+5.044	.003	.003	1	3
CNS	MDGA2 →	+5.614	+5.044	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,180 associations by consensus.

TSC22D1 by PIAS1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →