PI4KB

Across TCGA pan-cancer cohorts, PI4KB Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PI4KB data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PI4KB Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PI4KB expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, LUSC, and ESCA are the cancer types where PI4KB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.151	0.662	<.001	48	view →
LUSC	DFS	Median	All	0.205	0.664	<.001	36	view →
ESCA	OS	Median	II,III,IV	0.124	0.703	<.001	30	view →
SARC	OS	Median	All	0.108	0.839	<.001	12	view →
UCEC	DFS	Median	All	0.964	0.625	.016	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PI4KB–HNSC (OS)

Open the HNSC breakdown →