PI4KB

Across TCGA pan-cancer cohorts, PI4KB RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PI4KB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PI4KB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PI4KB is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where PI4KB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PI4KB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.554	<.001	12	view →
THCA	Male	All	−0.452	<.001	10	view →
LIHC	Female	II,III,IV	+1.700	<.001	9	view →
KICH	Female	All	−0.788	<.001	8	view →
KIRC	Female	All	+0.387	<.001	7	view →
STAD	Male	II,III,IV	+0.530	.015	4	view →
BRCA	All	II,III,IV	+0.208	.002	4	view →
CHOL	Male	All	+2.713	<.001	3	view →
LUAD	All	All	+0.234	.003	3	view →
LUSC	All	All	+0.240	.005	2	view →
KIRP	Male	All	−0.290	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PI4KB–HNSC

Open the HNSC breakdown →