PI4KB

Across TCGA pan-cancer cohorts, PI4KB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PI4KB data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PI4KB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PI4KB expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where PI4KB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.104	0.989	.003	34	view →
PDAC	OS	Median	All	0.464	0.295	.005	33	view →
LSCC	OS	Quartile	All	0.808	0.934	.014	14	view →
LUAD	OS	Quartile	III,IV	1.000	0.247	.016	8	view →
GBM	OS	Quartile	All	0.530	0.246	.007	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PI4KB–CCRCC (OS)

Open the CCRCC breakdown →