PI4KB

Across TCGA patient cohorts, PI4KB mutation is significantly associated with the RNA expression of many other genes, with 2,528 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI4KB-associated genes across cancer lineages are RBM22P7, ABITRAMP1, and RNU6-840P. Each is linked with PI4KB in more than 2 cancer types. Because this analysis shows association rather than direction, both PI4KB-to-partner and partner-to-PI4KB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBM22P7 grouped by PI4KB-low versus PI4KB-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4KB→partner) and Y-score (partner→PI4KB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RBM22P7 →	+0.067	+7.473	<.001	.007	3	3
HNSC	ABITRAMP1 →	+0.112	+4.716	<.001	.003	3	2
SKCM	RNU6-840P →	+0.421	+3.393	<.001	.001	3	2
SKCM	MIR4719 →	+0.172	+4.900	<.001	.002	3	2
SKCM	MIR4739 →	+0.180	+4.408	<.001	.005	3	2
BRCA	RNU6-336P →	+0.409	+4.721	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,528 associations by consensus.

RBM22P7 by PI4KB expression — BRCA

Explore this box plot interactively →