PI4KB

Across TCGA patient cohorts, PI4KB mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI4KB-associated genes across cancer lineages are eEF2, STAT3_pY705, and 14-3-3_beta. Each is linked with PI4KB in more than 1 cancer types. Because this analysis shows association rather than direction, both PI4KB-to-partner and partner-to-PI4KB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PI4KB-low versus PI4KB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4KB→partner) and Y-score (partner→PI4KB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.272	+2.584	.034	.010	3	2
UCEC	STAT3_pY705 →	-0.400	-2.807	<.001	.002	3	2
UCEC	14-3-3_beta →	-0.112	-3.432	.001	.005	3	1
UCEC	EGFR_pY1068 →	-0.194	-2.115	.032	.017	3	1
UCEC	eIF4E →	+0.184	+2.700	.015	.006	3	1
UCEC	ERK2 →	+0.184	+1.906	.007	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eEF2 by PI4KB expression — UCEC

Explore this box plot interactively →