PI4KB

Across TCGA cell cohorts, PI4KB mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PI4KB-associated genes across cancer lineages are UCN3, GHRHR, and TNP2. Each is linked with PI4KB in more than 1 cancer types. Because this analysis shows association rather than direction, both PI4KB-to-partner and partner-to-PI4KB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UCN3 grouped by PI4KB-low versus PI4KB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4KB→partner) and Y-score (partner→PI4KB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UCN3 →	+0.024	+3.855	<.001	.007	3	2
BLOOD_Leukemia	GHRHR →	+0.322	+3.705	<.001	.007	3	1
BLOOD_Leukemia	TNP2 →	+0.052	+4.037	<.001	.004	3	1
BLOOD_Leukemia	ETDB →	+0.041	+3.551	.003	.009	3	1
BLOOD_Leukemia	TLE7 →	+0.025	+4.384	<.001	.006	3	1
OVARY	ZP2 →	+0.024	+3.263	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

UCN3 by PI4KB expression — BLOOD_Leukemia

Explore this box plot interactively →