PI4KAP1

Across TCGA patient cohorts, PI4KAP1 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI4KAP1-associated genes across cancer lineages are MIR425, RNU6-642P, and KRTAP20-3. Each is linked with PI4KAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PI4KAP1-to-partner and partner-to-PI4KAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR425 grouped by PI4KAP1-low versus PI4KAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4KAP1→partner) and Y-score (partner→PI4KAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR425 →	+0.601	+3.236	<.001	.001	3	1
UCEC	RNU6-642P →	+0.383	+3.242	<.001	.007	3	1
UCEC	KRTAP20-3 →	+0.137	+5.253	<.001	.001	3	1
UCEC	RNU6-4P →	+0.704	+4.064	<.001	<.001	3	1
UCEC	TRAJ57 →	+0.628	+2.997	<.001	.005	3	1
UCEC	IGHD3-9 →	+2.226	+3.342	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

MIR425 by PI4KAP1 expression — UCEC

Explore this box plot interactively →