PI4KA

Across TCGA pan-cancer cohorts, PI4KA Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated PI4KA data layer compared with 19 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PI4KA Mutation is associated with better overall survival. In most high-consensus cancer types, elevated PI4KA expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, LUAD, and SKCM are the cancer types where PI4KA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.951	0.451	.008	30	view →
LUAD	OS	Median	II,III,IV	0.231	0.685	<.001	23	view →
SKCM	OS	Median	All	0.991	0.861	.006	14	view →
UCS	OS	Median	III,IV	0.135	0.590	.048	12	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →
BLCA	OS	Median	III,IV	1.000	0.644	.031	4	view →
READ	OS	Median	II,III,IV	0.187	0.653	.030	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
LIHC	DFS	Median	All	0.205	0.560	.002	3	view →
HNSC	OS	Median	II,III,IV	0.283	0.674	.016	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

PI4KA–UCEC (OS)

Open the UCEC breakdown →