PI4KA

Across TCGA pan-cancer cohorts, PI4KA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PI4KA data layer compared with 19 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PI4KA mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PI4KA expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where PI4KA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	IV	0.124	0.961	.038	16	view →
HNSC	OS	Quartile	III,IV	0.495	0.807	.010	14	view →
LSCC	DFS	Quartile	All	0.701	0.933	.010	12	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
LUAD	OS	Quartile	All	1.000	0.919	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PI4KA–CCRCC (OS)

Open the CCRCC breakdown →