PI4KA

Across TCGA patient cohorts, PI4KA protein abundance is significantly associated with the RNA expression of many other genes, with 10,678 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PI4KA-associated genes across cancer lineages are NEGR1, SYNE1, and ZCCHC24. Each is linked with PI4KA in more than 6 cancer types. Because this analysis shows association rather than direction, both PI4KA-to-partner and partner-to-PI4KA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PI4KA versus NEGR1 in COAD, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4KA→partner) and Y-score (partner→PI4KA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NEGR1 →	+0.643	+0.168	<.001	.008	3	7
LUAD	SYNE1 →	+0.709	+0.152	.001	.003	3	6
COAD	ZCCHC24 →	+0.951	+0.215	<.001	<.001	3	6
GBM	NAP1L3 →	+0.889	+0.322	<.001	<.001	3	6
OV	ZEB1 →	+1.093	+0.212	.001	.005	3	6
COAD	MYH11 →	+1.607	+0.165	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,678 associations by consensus.

PI4KA vs NEGR1 — COAD

Explore this scatter interactively →