PI4KA

Across TCGA patient cohorts, PI4KA mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI4KA-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and 4E-BP1_pT37_T46. Each is linked with PI4KA in more than 4 cancer types. Because this analysis shows association rather than direction, both PI4KA-to-partner and partner-to-PI4KA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PI4KA-low versus PI4KA-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4KA→partner) and Y-score (partner→PI4KA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Caspase-7-cleavedD198 →	+0.662	+3.000	.023	.034	3	5
UCEC	ATM →	-0.450	-1.584	<.001	<.001	3	4
STAD	4E-BP1_pT37_T46 →	-0.391	-3.169	.021	.018	3	3
BLCA	ACC_pS79 →	+0.443	+2.999	.017	.035	3	3
UCEC	eEF2 →	+0.228	+1.584	.019	.015	3	3
UCEC	Ku80 →	+0.233	+1.428	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Caspase-7-cleavedD198 by PI4KA expression — BLCA

Explore this box plot interactively →