PI4KA

Across TCGA cell cohorts, PI4KA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,714 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PI4KA-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Cytosolic transport. Each is linked with PI4KA in more than 19 cancer types. Because this analysis shows association rather than direction, both PI4KA-to-partner and partner-to-PI4KA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by PI4KA-low versus PI4KA-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4KA→partner) and Y-score (partner→PI4KA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Symbiont-mediated disruption of host cellular anatomical structure →	+0.181	+1.216	<.001	<.001	3	20
BREAST	Symbiont-mediated disruption of host anatomical structure →	+0.181	+1.216	<.001	<.001	3	20
SKIN	Cytosolic transport →	+0.083	+1.069	<.001	<.001	3	16
BLOOD_Myeloma	Interleukin-34-mediated signaling pathway →	+0.232	+1.317	<.001	<.001	3	15
SKIN	Endosomal transport →	+0.073	+1.454	<.001	<.001	3	15
OVARY	Regulation of Golgi inheritance →	+0.182	+0.895	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,714 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by PI4KA expression — BREAST

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