PI4K2A

Across TCGA patient cohorts, PI4K2A RNA expression is significantly associated with the protein abundance of many other proteins, with 14,234 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PI4K2A-associated proteins across cancer lineages are PPP1R18_S224, NRBF2, and PGAM1_S31. Each is linked with PI4K2A in more than 5 cancer types. Because this analysis shows association rather than direction, both PI4K2A-to-partner and partner-to-PI4K2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PI4K2A versus PPP1R18_S224 in PDAC, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4K2A→partner) and Y-score (partner→PI4K2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PPP1R18_S224 →	+0.540	+0.390	<.001	<.001	3	6
CCRCC	NRBF2 →	+0.507	+0.499	<.001	<.001	3	6
LSCC	PGAM1_S31 →	+0.576	+0.415	<.001	<.001	3	5
COAD	PPP1R18 →	+0.480	+0.556	<.001	<.001	3	5
GBM	TBC1D2B →	+0.370	+0.520	<.001	<.001	3	5
OV	PPFIBP1 →	+0.284	+0.277	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,234 associations by consensus.

PI4K2A vs PPP1R18_S224 — PDAC

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