PI4K2A

Across TCGA patient cohorts, PI4K2A mutation is significantly associated with the RNA expression of many other genes, with 2,169 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI4K2A-associated genes across cancer lineages are TRDJ4, RN7SL248P, and MIR596. Each is linked with PI4K2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PI4K2A-to-partner and partner-to-PI4K2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDJ4 grouped by PI4K2A-low versus PI4K2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI4K2A→partner) and Y-score (partner→PI4K2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRDJ4 →	+0.609	+5.122	<.001	.004	3	2
UCEC	RN7SL248P →	+0.049	+2.915	<.001	.007	3	2
UCEC	MIR596 →	+0.348	+1.944	<.001	.005	3	2
COAD	H2AC18 →	+0.110	+4.415	.007	.006	3	1
COAD	MIR147A →	+0.481	+4.893	.001	.005	3	1
COAD	TRGJP1 →	+0.712	+4.754	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,169 associations by consensus.

TRDJ4 by PI4K2A expression — COAD

Explore this box plot interactively →