PI16

Across TCGA cell cohorts, PI16 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PI16-associated genes across cancer lineages are USP17L4 and TBC1D3. Each is linked with PI16 in more than 1 cancer types. Because this analysis shows association rather than direction, both PI16-to-partner and partner-to-PI16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L4 grouped by PI16-low versus PI16-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI16→partner) and Y-score (partner→PI16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	USP17L4 →	+0.013	+5.209	<.001	.005	3	1
LARGE_INTESTINE	TBC1D3 →	+0.077	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

USP17L4 by PI16 expression — BLOOD_Lymphoma

Explore this box plot interactively →