PI15

Across TCGA cell cohorts, PI15 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PI15-associated genes across cancer lineages are CT45A7, CDH20, and OR14K1. Each is linked with PI15 in more than 1 cancer types. Because this analysis shows association rather than direction, both PI15-to-partner and partner-to-PI15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT45A7 grouped by PI15-low versus PI15-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI15→partner) and Y-score (partner→PI15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CT45A7 →	+0.047	+4.209	.003	.006	3	1
LARGE_INTESTINE	CDH20 →	+0.103	+4.029	<.001	.001	3	1
LARGE_INTESTINE	OR14K1 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	NPY2R →	+0.003	+3.217	<.001	.006	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.044	+2.994	.001	.006	3	1
LARGE_INTESTINE	ASPN →	+0.051	+3.426	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CT45A7 by PI15 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →