PHYHIPL

Across TCGA cell cohorts, PHYHIPL mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHYHIPL-associated genes across cancer lineages are ODF3, SLC16A12, and PTH2R. Each is linked with PHYHIPL in more than 1 cancer types. Because this analysis shows association rather than direction, both PHYHIPL-to-partner and partner-to-PHYHIPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF3 grouped by PHYHIPL-low versus PHYHIPL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYHIPL→partner) and Y-score (partner→PHYHIPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ODF3 →	+0.056	+3.836	<.001	.003	3	1
LARGE_INTESTINE	SLC16A12 →	+0.678	+3.710	<.001	.008	2	1
LARGE_INTESTINE	PTH2R →	+0.655	+3.453	.008	.009	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ODF3 by PHYHIPL expression — LARGE_INTESTINE

Explore this box plot interactively →