PHYHIP

Across TCGA patient cohorts, PHYHIP mutation is significantly associated with the RNA expression of many other genes, with 1,391 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHYHIP-associated genes across cancer lineages are OR7E21P, UQCR10, and RPL23AP82. Each is linked with PHYHIP in more than 1 cancer types. Because this analysis shows association rather than direction, both PHYHIP-to-partner and partner-to-PHYHIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E21P grouped by PHYHIP-low versus PHYHIP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYHIP→partner) and Y-score (partner→PHYHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR7E21P →	+0.055	+3.043	<.001	.006	3	2
UCEC	UQCR10 →	+0.400	+3.491	.001	.002	3	2
UCEC	RPL23AP82 →	+0.421	+3.010	.001	<.001	3	2
UCEC	NDUFA6 →	+0.477	+2.332	<.001	.003	3	2
UCEC	TMEM120B →	+0.430	+3.218	.001	.009	3	2
UCEC	CDPF1 →	+0.361	+2.740	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,391 associations by consensus.

OR7E21P by PHYHIP expression — SKCM

Explore this box plot interactively →