PHYH

Across TCGA pan-cancer cohorts, PHYH mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PHYH data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PHYH mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PHYH expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where PHYH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	1.000	0.451	.016	30	view →
HNSC	DFS	Quartile	All	0.520	0.825	.005	21	view →
PDAC	DFS	Median	All	0.443	0.209	.002	15	view →
LUAD	DFS	Tertile	All	0.537	0.911	.025	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PHYH–CCRCC (OS)

Open the CCRCC breakdown →