PHYH

Across TCGA patient cohorts, PHYH mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHYH-associated genes across cancer lineages are ATM, 4E-BP1, and A-Raf_pS299. Each is linked with PHYH in more than 1 cancer types. Because this analysis shows association rather than direction, both PHYH-to-partner and partner-to-PHYH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PHYH-low versus PHYH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYH→partner) and Y-score (partner→PHYH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.389	-1.362	.015	.037	3	2
UCEC	4E-BP1 →	+0.240	+3.169	.011	.018	3	2
UCEC	A-Raf_pS299 →	-0.085	-1.362	.044	.037	3	1
UCEC	JNK2 →	+0.286	+2.000	<.001	.003	3	1
UCEC	Ku80 →	+0.281	+1.676	<.001	.007	3	1
UCEC	MEK1 →	+0.429	+2.584	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ATM by PHYH expression — UCEC

Explore this box plot interactively →